MouseAdventure in a Box is a series of quests that are solved one at a time. Once you have successfully solved the first quest, the second quest is available for your team to solve and so on. Each quest has a physical portion that is contained in the mailed box, as well as an online portion that is accessed via the game webpages. Each game is designed to take about four hours on average to complete. Some teams will take longer and some less time.

For Competitive division teams, total game time is tracked and the final finish time is calculated based on that plus any penalties for hints taken along the way. On Your Time division teams are not ranked.

In game assistance is provided by the Third Gate Games team for Competitive division teams on game day. Built in hints on quest pages provide self-service assistance to On Your Own Time teams.